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Why antidepressants can stop working after initially helping

By Colin Davidson, Professor of Neuropharmacology, University of Lancashire

Antidepressant use continues to rise. In England, 96 million antidepressant prescription items were dispensed to an estimated 9.1 million patients in 2025 to 2026. These medicines are prescribed for depression and other conditions, including anxiety and some forms of pain.

Antidepressants can take several weeks to work fully, can cause unwanted side effects…

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