How to build a digital ‘twin’ of the human brain – what existing models overlook

By Andrea Luppi, Senior Research Associate, Department of Psychiatry, University of Oxford
Gustavo Deco, Professor of Computational Neuroscience, Center for Brain and Cognition, Universitat Pompeu Fabra
Morten L. Kringelbach, Professor of Neuroscience, University of Oxford

The potential to create personalised digital “twins” of your brain and body is a hot topic in neuroscience and medicine today. These computer models are designed to simulate how parts of your brain interact, and how the brain may respond to stimulation, disease or medication.

The extraordinary complexity of the brain’s billions of neurons makes this a very difficult task, of course, even in the era of AI and big data. Until now, whole-brain models…

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