Why it's still a scientific mystery how some can live past 100 – and how to crack it

By Richard Faragher, Professor of Biogerontology, University of Brighton
Nir Barzilai, Professor of Medicine and Genetics, Albert Einstein College of Medicine

A 35-year-old man only has a 1.5% chance of dying in the next ten years. But the same man at 75 has a 45% chance of dying before he reaches 85. Clearly, ageing is bad for our health. On the bright side, we have made unprecedented progress in understanding the fundamental mechanisms that control ageing and late-life disease.

A few tightly linked biological processes, sometimes called the “hallmarks of ageing”, including our supply of stem cells…

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